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A framework for the design, conduct and interpretation of randomised controlled trials in the presence of treatment changes

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Abstract Background When a randomised trial is subject to deviations from randomised treatment. analysis according to intention-to-treat does not estimate two important quantities: relative treatment efficacy and effectiveness in a setting different from that in the trial. Even in trials of a predominantly pragmatic nature. there may be numerous reasons to consider the extent. https://www.classiquesupplyes.shop/product-category/wax-essentials/
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