In practice and despite Anfinsen’s dogma. the refolding of recombinant multiple SS-bonded proteins is famously difficult because misfolded species with non-native SS-bonds appear upon the oxidization of their cysteine residues. On the other hand. single SS-bond proteins are thought to be simple to refold because their cysteines have only one SS-bond partner. https://www.roomyroomers.shop/product-category/pocketed-spring-mattress/